Endocrine Abstracts

Breast cancer (BCa) patients who present at clinic with elevated circulating LDL-cholesterol have poor prognosis, whilst pharmacological and lifestyle interventions that lower circulating cholesterol (statins, exercise, low saturated fat intake etc.) are associated with better treatment efficacy. The molecular mechanisms that link cholesterol with chemotherapy resistance (CR) remain unexplored. Hydroxycholesterols (OHCs) activate the transcription factor LXR, and are formed in...